Launched in October 2023, the Center for Respiratory Biology and Therapeutics brings together scientific research teams to build a transformative “bench to bedside and back” platform to drive the next phase of discoveries and novel therapeutics. Researchers at the center aim to improve care for children with respiratory disease and train the next generation of respiratory researchers.
Through clinical practice and innovative clinical trials, center researchers bring next phase therapeutics and treatments to improve care for children with respiratory diseases. Propelled by innovative research, Seattle Children’s pediatric pulmonary and lung surgery program is ranked among the top ten in the nation. Many of the center’s members see patients through Seattle Children’s Airway and Esophogeal Center, which is the only center in the Pacific Northwest that provides care for patients with complex conditions affecting their airway and esophagus.
The center provides the space, capabilities, and resources needed for clinical, basic, translational, epidemiologic, community health, and global health focused investigators to advance discoveries that will enable development, testing and implementation of new therapies to improve care for children and all patients with respiratory diseases across the lifespan.
There is palpable enthusiasm around the work that is ongoing and the potential opportunities within CRBT. It’s incredibly exciting.
- Dr. Terri Laguna, division chief of pulmonary and sleep medicine at Seattle Children’s and cystic fibrosis researcher at the Center for Respiratory Biology and Therapeutics
Read about the Center for Respiratory Biology and Therapeutics: A fresh breath for respiratory research on Nature.
Leadership and Governance
Jason S. Debley, MD, MPH, is the director of the Center for Respiratory Biology and Therapeutics, an attending physician in the Pulmonary and Sleep Medicine Division at Seattle Children's Hospital and a professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD from Northwestern University Medical School and completed his pediatrics internship and residency at Children’s Memorial Hospital in Chicago, Illinois. He completed his pediatric pulmonary fellowship at Seattle Children’s and earned an MPH from the University of Washington. He has clinical expertise in severe asthma, recurrent wheezing of early childhood, bronchopulmonary dysplasia, restrictive lung diseases of childhood and the management of chronic respiratory failure.
Members of the CRBT Leadership Team meet monthly to discuss scientific strategy planning and governance for the center.
CRBT researcher meetings
All CRBT researchers are invited to attend quarterly meetings to provide their feedback on scientific strategic planning.
For more information regarding CRBT governance and CRBT researcher meetings, please send us an email us.
If you are currently a member of CRBT, please see the center’s page on CHILD for member resources.
Key Partnerships
Cystic Fibrosis Therapeutics Development Network
The Cystic Fibrosis Therapeutics Development Network (TDN) is the largest cystic fibrosis (CF) clinical trials network in the world, bringing together experts from across the country to evaluate the safety and effectiveness of new CF therapies through clinical studies. The TDN has supported over 150 industry- and investigator-initiated studies across more than 90 sites in the United States. Learn more.
New therapies that have transformed the lives of patients with CF around the world have been advanced to the bedside and tested at Seattle Children’s through this partnership.
Drs. Nicole Hamblett and Christopher Goss serve as co-executive directors of the Cystic Fibrosis Therapeutics Development Network Coordinating Center.