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CAR T Cell Trafficking Into Gliomas

An illustraion of CAR T cell trafficking into gliomas This project develops an advanced mouse model of chimeric antigen receptor (CAR) T cell cancer immunotherapy for malignant brain tumors, which has been challenging in the clinical setting because of limited ability of the CAR T cells to travel to the tumors and survive in the hostile microenvironment.

We will use an immunocompetent transgenic mouse model to induce brain-intrinsic tumors via viral delivery of oncogenes into brain progenitor cells, and image the tumor growth and CAR T cell infiltration into the tumor using two-photon microscopy via a cranial window.

This model enables us to study of molecular mechanisms of CAR T cell targeting against brain tumors by manipulating T cell guidance cues, T cell signal recognition, and adhesion molecule activation.

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.