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Projects

Disrupting heterochromatin to enhance reprogramming of fibroblasts to hepatocyte like cells for liver cell therapy and transplantation
Disrupting heterochromatin to enhance reprogramming of fibroblasts to hepatocyte like cells for liver cell therapy and transplantation

Liver transplantation is the only curative treatment for most liver diseases, but the supply of donor liver tissue is not enough to meet the demand.

H3K9me3 heterochromatin regulation during development

Development successfully establishes and rearranges heterochromatin to generate a multitude of cell fates and functions; understanding this process provides new tools for manipulating cell identity.

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.