Shaun W Jackson, MD, PhD

Shaun W Jackson, MD, PhD

Specialties

"My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis."

  • Biography

    Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Children's Hospital and an Associate Professor of Pediatrics of Pediatrics at the University of Washington School of Medicine. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Children's Hospital / University of Washington.

    Dr. Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.

    Board Certification(s)

    Pediatric Rheumatology
    Pediatric Nephrology

    Education

    University of Cape Town, Observatory, Cape Town

    Fellowship

    University of Washington School of Medicine, Seattle, WA

    Clinical Interests

    My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.

    Research Description

    My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.

  • Related Resources

    • Jackson Lab

      Jackson Lab

      The Jackson Lab studies the immune mechanisms underlying the development of systemic autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.

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  • Awards and Honors

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  • Publications

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